A Multi-Domain Connectome Convolutional Neural Network for Identifying Schizophrenia from EEG Connectivity Patterns

Phang, Chun-Ren; Noman, Fuad Mohammed; Hussain, Hadri; Ting, Chee-Ming; Ombao, Hernando

A Multi-Domain Connectome Convolutional Neural Network for Identifying Schizophrenia from EEG Connectivity Patterns

Files

08836535.pdf (1.65 MB)

Type

Article

Authors

Phang, Chun-Ren
Noman, Fuad Mohammed
Hussain, Hadri
Ting, Chee-Ming
Ombao, Hernando

KAUST Department

Statistics Program, King Abdullah University of Science and Technology, Thuwal 23955, Saudi Arabia
Statistics Program
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Online Publication Date

2019-09-13

Print Publication Date

2019

Date

2019-09-13

Abstract

Objective: We exploit altered patterns in brain functional connectivity as features for automatic discriminative analysis of neuropsychiatric patients. Deep learning methods have been introduced to functional network classification only very recently for fMRI, and the proposed architectures essentially focused on a single type of connectivity measure. Methods: We propose a deep convolutional neural network (CNN) framework for classification of electroencephalogram (EEG)-derived brain connectome in schizophrenia (SZ). To capture complementary aspects of disrupted connectivity in SZ, we explore combination of various connectivity features consisting of time and frequency-domain metrics of effective connectivity based on vector autoregressive model and partial directed coherence, and complex network measures of network topology. We design a novel multi-domain connectome CNN (MDC-CNN) based on a parallel ensemble of 1D and 2D CNNs to integrate the features from various domains and dimensions using different fusion strategies. We also consider an extension to dynamic brain connectivity using the recurrent neural networks. Results: Hierarchical latent representations learned by the multiple convolutional layers from EEG connectivity reveal apparent group differences between SZ and healthy controls (HC). Results on a large resting-state EEG dataset show that the proposed CNNs significantly outperform traditional support vector machine classifiers. The MDC-CNN with combined connectivity features further improves performance over single-domain CNNs using individual features, achieving remarkable accuracy of 91.69% with a decision-level fusion. Conclusion: The proposed MDC-CNN by integrating information from diverse brain connectivity descriptors is able to accurately discriminate SZ from HC. Significance: The new framework is potentially useful for developing diagnostic tools for SZ and other disorders.

Citation

Phang, C.-R., Noman, F., Hussain, H., Ting, C.-M., & Ombao, H. (2020). A Multi-Domain Connectome Convolutional Neural Network for Identifying Schizophrenia From EEG Connectivity Patterns. IEEE Journal of Biomedical and Health Informatics, 24(5), 1333–1343. doi:10.1109/jbhi.2019.2941222